李瑞金

李瑞金,山西大学环境科学研究所教师,环境科学专业博士,教授,博士生导师,研究方向为环境污染与健康。

主要学习和教学科研经历:

1985.9-1989.6  山西大学环保系本科毕业,获理学学士学位;

1989.7-2001.8  在太化职工大学任教;

2001.9-2004.6  山西大学环境科学专业硕士研究生毕业,2004年获工学硕士学位;

2004.9-2007.6  山西大学环境科学专业博士研究生毕业,2007年获工学博士学位;

2004.7-2008.10  山西大学环境科学与工程研究中心,讲师

2008.11-2015.11 山西大学环境科学研究所,副教授

2015.12-至      山西大学环境科学研究所,教授

2008.12-2011.6 山西大学生物学博士后流动站工作;

2011.11-2012.5 美国加州大学河滨分校访问研究;

2013.3-2013.9  香港浸会大学访问研究;

2016.1-2016.7  香港浸会大学访问研究;

2017.4-2017.8  香港浸会大学访问研究;

2023.12.30-2024.6.30  澳大利亚西澳大学访问研究。

主要科研成果:

一、 主要学术论文

发表学术论文117,其中SCI核心期刊收录论文79篇(第一作者21篇,通讯作者29篇)。

1. Fu P, Zhang M, Bai L, Chen S, Chen W, Li Z, Yue J, Dong C, Li R*. Intestinal Bacterial Dysbiosis and Liver Fibrosis in Mice Through Gut-Liver Axis and NLRP3 Inflammatory Pathway Caused by Fine Particulate Matter. J Appl Toxicol. 2025 Feb 20. doi: 10.1002/jat.4767.

2. Bai L, Fu P, Dong C, Li Z, Yue J, Li X, Cao Q, Han Y, Zhang S*, Li R*.Study of association between embryo growth arrest (EGA) and atmospheric fine particulate matter pollution (PM2.5) and spatial metabolomics of villi derived from pregnant women. Journal of Hazardous Materials, 2025, 485,136833.

3. Zhao K, Lin B, Ma L, Zan Q, Wang R, Li R*, Wang Y, Shuang S, Dong C, Fan L*. Lipid droplet-targetable fluorescent probe for imaging viscosity in PM2.5 exposure-induced lung injury, non-alcoholic fatty liver, and tumor models. Microchemical Journal, 2024, 205, 111193.

4. Ma H, Wu ZT, Li R*. Analysis of the spatial and temporal scale effects of landscape pattern index on carbon sinks in green spaces in Taiyuan, China. Journal of Urban Planning and Development,2025, 151(1): 05024039.

5. Chen, F.; Liu, Y.; Guo, J.; Bai,H.; Wu, Z.; Liu, Y.*; Li, R*. Assessing carbon sink capacity in coal mining areas: A case study from Taiyuan city, China. Atmosphere 2024, 15, 765. https://doi.org/10.3390/atmos15070765

6. Chen, F., Liu, Y. & Li, R*. Low-carbon development path based on carbon emission accounting and carbon emission performance evaluation: a case study of Chinese coal production enterprises. Environ Sci Pollut Res 2024,31, 45522–45536.

7. Chen,W.; Chen, S.; Bai, L.;Li, R*. Combined Exposure to High-Cholesterol Diet and PM2.5: Brain Injury and Regulatory Mechanism of HIF-1α in ApoE−/−Female Mice. Atmosphere 2024, 15, 952.https://doi.org/10.3390/atmos15080952

8. Zhang, M.; Chen, S.; Bai, L.; Chen,W.; Li, R*. Protective Effects of Resveratrol on Cytotoxicity of Mouse Hepatic Stellate Cells Induced by PM2.5. Atmosphere 2024, 15, 588.

9. Li R*, Zhao C, Zhang Y, Huang W, Wang J, Cao G, Cai Z*. PM2.5-induced DNA oxidative stress in A549 cells and regulating mechanisms by GST DNA methylation and Keap1/Nrf2 pathway. Toxicology Mechanisms and Methods, 2024,34(5): 517-526.

10. Bai L, Zhang M, Chen S, Chen W, Li Z, Yue J, Dong C, Li R*. Pollution characteristics of different components of PM2.5 in Taiyuan during 2017-2020 wintertime and their toxicity effects on HepG2 cells, Atmosphere, 2024,15,32.

11. Li Z, Hao Q, Yue J, Qin J, Dong C, Yung KKL*, Li R*.Pollution characteristics and health risk assessment of PM2.5-bound polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs and halogenated-PAHs in Shanxi, China.

Air Quality, Atmosphere & Health, 2024,17:723–735.https://doi.org/10.1007/s11869-023-01475-1

12. Chen S, Chen W, Li Z, Yue J, Yung KKL*, Li R*.The regulatory mechanism of PM2.5 on mitochondrial damage in H9c2 cells through miR-421/SIRT3 pathway and the protective effect of miR-421 inhibitor and resveratrol. Journal of Environmental Sciences, 2024, 138:288-300.

13. Fu P, Li R, Sze SCW*, Yung KKL*. Associations between fine particulate matter and colorectal cancer: A systematic review and meta-analysis. Reviews on Environmental Health, 2023,39(3):447-457. doi: 10.1515/reveh-2022-0222.

14. Wang W, Cao G, Zhang J, Wu P, Chen Y, Chen Z, Qi Z, Li R, Dong C, Cai Z. Beyond Substituted p-Phenylenediamine Antioxidants: Prevalence of Their Quinone Derivatives in PM2.5. Environ Sci Technol. 2022;56(15):10629-10637. doi: 10.1021/acs.est.2c02463.

15. Yang S, Wen L, Chai X, Song Y, Chen X, Chen ZF, Li R, Dong C, Qi Z*, Cai Z*. The protective effects of taurine and fish oil supplementation on PM2.5-induced heart dysfunction among aged mice: A random double-blind study. Sci Total Environ, 2022, 851(Pt 1):157966.

16. Zhang M, Wang Y, Wong Ricky M. S., Yung K. K. L.,* Li R*. Fine particulate matter induces endoplasmic reticulum stress-mediated apoptosis in human SH-SY5Y cells. Neurotoxicology, 2022,88:187-196.

17. Chen W, Chen S, Zhao L, Zhang M, Geng H, Dong C, Li R*. Effects of real-ambient PM2.5 exposure plus lipopolysaccharide on multiple organ damage in mice. Human and Experimental Toxicology, 2022, 41: 9603271211061505.

18. Zhao L, Zhang M, Bai L, Zhao Y, Cai Z, Yung KKL, Dong C*, Li R*.Real-world PM2.5 exposure induces pathological injury and DNA damage associated with miRNAs and DNA methylation alteration in rat lungs. Environmental Science and Pollution Research, 2022, 29(19):28788-28803.

19. Fu P, Zhao Y, Dong C, Cai Z, Li R*, Yung KKL*. An integrative analysis of miRNA and mRNA expression in the brains of Alzheimer’s disease transgenic mice after real-world PM2.5 exposure. Journal of Environmental Sciences, 2022,122:25-40.

20. Bai L, Tan Z, Gong H, Xu M, Li Z,Yue J, Liu L, Yang D*, Li R*. Study on antibiotics, antibiotic resistance genes, bacterial community characteristics and their correlation in the landfill leachates.Journal of Applied Microbiology, 2022,132:445-458.

21. Bai L, Zhao Y, Zhao L, Zhang M, Cai Z, Yung KKL, Dong C*, Li R*. Ambient air PM2.5 exposure induces heart injury and cardiac hypertrophy in rats through regulation of miR-208a/b, α/β-MHC, and GATA4. Environmental Toxicology and Pharmacology, 2021, 85, 103653.

22. Zhao C, Xie P, Yong T, Huang W, Liu J, Wu D, Ji F, Li M, Zhang D, Li R, Dong C, Ma J, Dong Z, Liu S, Cai Z*. Airborne fine particulate matter induces cognitive and emotional disorders in offspring mice exposed during pregnancy. Science Bulletin, 2021, 66(6):578-591.

23. Song Y, Qi Z, Zhang Y, Wei J, Liao X, Li R, Dong C, Zhu L, Yang Z, Cai Z*. Effects of exposure to ambient fine particulate matter on the heart of diet-induced obesity mouse model. Sci Total Environ. 2020,732:139304.

24. Song Y, Zhao L, Qi Z, Zhang Y, Cao G, Li R, Zhu L, Yang Z, Dong C, Cai Z*. Application of a real-ambient fine particulate matter exposure system on different animal models. Journal of Environmental Sciences, 2021, 105: 64-70.

25.Li R, Zhao Y, Shi J, Zhao C, Xie P, Huang W, Yong T, Cai Z*. Effects of PM2.5 exposure in utero on heart injury, histone acetylation and GATA4 expression in offspring mice. Chemosphere, 2020年5月,256,127133

26. Zhao Y, Mao W, Pang L, Li R*, Li S*. Influence of Phragmites communis and Zizania aquatica on rhizosphere soil enzyme activity and bacterial community structure in a surface flow constructed wetlands treating secondary domestic effluent in China.Environ. Sci. Pollut. Res., 2020,May,27:26141–26152.

27. Fu P, Bai L, Cai Z, Li R*, Yung KKL*. Fine particulate matter aggravates intestinal and brain injury and affects bacterial community structure of intestine and feces in Alzheimer's disease transgenic mice. Ecotoxicol Environ Saf. 2020, 192, 110325

28. Chen YJ, Zhang YH, Chen YY, Lu Y, Li R, Dong C, Qi Z, Liu G, Chen Z*, Cai Z*.GC-MS/MS analysis for source identification of emerging POPs in PM2.5. Ecotoxicol Environ Saf. 2020,193, 110368

29. Zhang M, Li Z, Xu M, Yue J, Cai Z, Yung KKL*, Li R*. Pollution characteristics, source apportionment and health risks assessment of fine particulate matter during a typical winter and summer time period in urban Taiyuan, China. Human and Ecological Risk Assessment: An International Journal,2020,26(10):2737-2750.

30.Song Y, Zhang Y, Li R, Chen W, Chung CKA, Cai Z*. The cellular effects of PM2.5 collected in Chinese Taiyuan and Guangzhou and their associations with polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs and hydroxy-PAHs. Ecotoxicol Environ Saf. 2020,191:110225.

31. Zhang Y, Song Y, Wu J, Li R, Hu D, Lin Z,Cai Z*.A magnetic covalent organic framework as an adsorbent and a new matrix for enrichment and rapid determination of PAHs and their derivatives in PM2.5by surface-assisted laser desorption/ionization-time of flight-mass spectrometry.Chem Commun (Camb),2019, 55(26):3745-3748. doi: 10.1039/c9cc00384c.

32. Zhang Y, Chen Y, Li R, Chen W, Song Y, Hu D,Cai Z.Determination of PM2.5-bound polyaromatic hydrocarbons and their hydroxylated derivatives by atmospheric pressure gas chromatography-tandem mass spectrometry.Talanta, 2019,195:757-763. doi: 10.1016/j.talanta.2018.12.006.

33. Wang Z, Gao S, Xie J*, Li R. Identification of multiple dysregulated metabolic pathways by GCMS-basedprofiling of liver tissue in mice with OVA-induced asthma exposed to PM2.5. Chemosphere, 2019, 234,277-286.

34. Zhao C, Zhu L, Li R, Wang H, Cai Z*. Omics approach reveals metabolic disorders associated with thecytotoxicity of airborne particulate matter in human lungcarcinoma cells. Environmental Pollution,2019, 246, 45-52.

35. Wang Z, Gao S, Xie J*, Li R. Identification of multiple dysregulated metabolic pathways byGC-MS-based profiling of lung tissue in mice with PM2.5-inducedasthma. Chemosphere, 2019, 220,1-10.

36.WangY, Zhang M, Li Z, Yue J, Xu M, Zhang Y, Yung KKL*, Li R*. Fine particulate matter induces mitochondrial dysfunction and oxidative stress in human SH-SY5Y cells. Chemosphere, 2019, 218,577-588.

37. Zhao L, Zhang L, Chen M, Dong C, Li R*, Cai Z*. Effects of ambient atmospheric PM2.5,1-Nitropyrene and 9-Nitroanthracene on DNA damage and oxidative stress in hearts of rats. Cardiovascular Toxicology, 2019,19,178-190.

38.Wang Y, Zhang M, Zhao L, Zhang W, Zhao T, Chu J, Qiu Y, Gong H, Li R*. Effects of tetrabromobisphenol A on maize ( Zea mays L. ) physiological indexes, soil enzyme activity, and soil microbial biomass. Ecotoxicology, 2019, 28, 1-12.

39. Chen Y, Chen Y, Zhang Y, Li R, Chen W, Yan S, Qi Z, Chen Z, Cai Z*. Determination of HFRs and OPFRs in PM2.5 by ultrasonic-assisted extraction combined with multi-segment column purification and GC-MS/MS. Talanta, 2019,194,320-328.

40. Qi Z, Song Y, Ding Q, Liao X, Li R, Liu G, Tsang S*, Cai Z*. Water soluble and insoluble components of PM2.5 and their functional cardiotoxicities on neonatal rat cardiomyocytes in vitro. Ecotoxicol Environ Saf. 2018, 168:378-387.

41. Song Y, Li R, Zhang Y, Wei J, Chen W, Chung CK.A, Cai Z*. Mass spectrometry-based metabolomics reveals the mechanism of ambient fine particulate matter and its components on energy metabolic reprogramming in BEAS-2B cells. Science of The Total Environment. 2019, 651, 3139-3150.

42. Li R, Zhang M, Wang Y, Yung KKL, Su R, Li Z., Zhao L, Dong C*, Cai Z*. Effects of atmospheric PM2.5 subchronic exposure on fibrosis, inflammation, endoplasmic reticulum stress and apoptosis in livers of rats.Toxicology Research, 2018,7, 271-282.

43. Zhang Y, Li R, Fang J, Wang C, Cai Z*. Simultaneous Determination of Eighteen Nitro-PolyaromaticHydrocarbons in PM2.5 by Atmospheric Pressure Gas Chromatography-Tandem Mass Spectrometry. Chemosphere. 2018,198, 303-310.

44. Lu W, Li R, Shuang S, Dong C*, Cai Z*. Reduced carbon nanodots as a novel substrate for direct analysis of bisphenol analogs in surface assisted laser desorption/ionization time of flight mass spectrometry. Talanta, 2018, 190,89-94.

45. Zhang Y, Yang Z, Chen Y, Li R, Geng H, Dong W, Cai Z*, Dong C*. Fine chalk dust induces inflammatory response via p38 and ERK MAPK pathway in rat lung.Environ Sci Pollut Res Int. 2018 Jan;25(2):1742-1751.

46. Jin X, Su R, Li R, Cheng L, Li Z*. Crucial role of pro-inflammatory cytokines from respiratory tract upon PM2.5 exposure in causing the BMSCs differentiation in cells and animals. Oncotarget, 2017, 9(2):1745-1759.

47. Jin X, Chen M, Li R, An Q, Song L, Zhao Y, Xiao H, Cheng L, Li Z*. Progression and inflammation of human myeloid leukemia induced by ambient PM2.5 exposure. Archives of Toxicology. 2016, 90(8), 1929-1938

48. Li R, Zhao L, Zhang L, Chen M, Shi J, Dong C*, Cai Z*. Effects of ambient PM2.5 and 9-nitroanthracene on DNA damage and repair, oxidative stress and metabolic enzymes in lungs of rats. Toxicology Research, 2017, 6(5):654-663.

49. Li R*,Zhao L, Zhang L, Tong J, Yan Y, Xu C. Fine particulate matter and sulfur dioxide co-exposures induce rat lung pathological injury and inflammatory responses via TLR4/p38/NF-κB pathway. International Journal of Toxicology, 2017,36(2):165-173.

50. Li R, Zhao L, Zhang L, Chen M, Dong C*, Cai Z*. DNA damage and repair, oxidative stress and metabolism biomarker responses in lungs of rats exposed to ambient atmospheric 1-nitropyrene. Environmental Toxicology and Pharmacology, 2017, 54, 14-20.

51. Yang Z, Chen Y, Zhang Y, Li R*, Dong C*. The role of pro-/anti-inflammation imbalance in Aβ42 accumulation of rat brain co-exposed to fine particle matter and sulfur dioxide. Toxicol Mech Methods. 2017, 27(8):568-574

52. Jin X, Su R, Li R, Song L, Chen M, Cheng L, Li Z*. Amelioration of particulate matter-induced oxidative damage by vitamin c and quercetin in human bronchial epithelial cells. Chemosphere 2016,144: 459-466. 2月

53. Lu W, Li Y, Li R, Shuang S, Dong C*, Cai Z*. Facile Synthesis of N-Doped Carbon Dots as a New Matrix for Detection of Hydroxy-Polycyclic Aromatic Hydrocarbons by Negative-Ion Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry. ACS Appl. Mater. Interfaces 2016, 8: 12976-12984. 5月

54. Li R, Kou X, Geng H, Xie J, Yang Z, Zhang Y, Cai Z *, Dong C*. Effect of ambient PM2.5 on lung mitochondrial damage and fusion/fission gene expression in rats. Chemical Research in Toxicology, 2015, 28(3): 408-418.

55. Li R, Kou X, Xie L, Cheng F*, Geng H*. Effects of ambient PM2.5 on pathological injury, inflammation, oxidative stress, metabolic enzyme activity and expression of c-fos and c-jun in lungs of rats. Environmental Science and Pollution Research, 2015, Dec;22(24):20167-76.

56. Li R, Kou X, Geng H, Xie J, Tian J, Cai Z*, Dong C*. Mitochondrial damage: an important mechanism of ambient PM2.5 exposure-induced acute heart injury in rats. Journal of Hazardous Materials 2015, 287C: 392-401

57. Zhang J, Zhang L, Li R, Hu D, Ma N, Shuang S, Cai Z*, Dong C*. Magnetic graphene composites as both adsorbent for sample enrichment and MALDI-TOF MS matrix for the detection of nitropolycyclic aromatic hydrocarbons in PM. Analyst 2015,140(5): 1711-6.

58. Ma N, Bian W, Li R, Geng H, Zhang J, Dong C, Shuang S*,Cai Z*. Efficient quantitative analysis of nitro-polycyclic aromatic hydrocarbons in PM2.5 samples by MALDI TOF MS with graphene as matrix. Analytical Methods,2015, 7: 3967-3971.

59. Zhang Y, Yang Z, Li R, Geng H*, Dong C*. Investigation of fine chalk dust particles’ chemical compositions and toxicities on alveolar macrophages in vitro. Chemosphere 2015, 120: 500-506.

60. Zhang Y, Yang Z, Zhang Q, Li R, Geng H*, Dong C*. Chemical compositions and effects on chemiluminescence of AMs in vitro of chalk dusts. Chinese Chemical Letters, 2015, 26(1): 157-159.

61. Zhang Y, Yang Z, Feng Y, Li R, Zhang Q, Geng H*, Dong C*. Effects of coarse chalk dust particles (2.5–10 μm) on respiratory burst and oxidative stress in alveolar macrophages. Environ Sci Pollut Res,2015, 22: 12450-12457.

62.  Ma N, Zhang L, Li R, Zhou Y, Cai Z, Dong C, Shuang S. Magnetic solid-phase extraction based on a trimethylstearylammonium bromide coated Fe3O4/SiO2 composite for determination of adriamycin hydrochloride in human plasma and urine by HPLC-FLD. Anal. Methods, 2014, 6: 6736-6744.

63. Li R, Kou X, Tian J, Meng Z, Cai Z, Cheng F*, Dong C*. Effect of sulfur dioxide on inflammatory and immune regulation in asthmatic rats. Chemosphere 2014, 122: 296-304.

64. Li R, Kou X, Geng H, Dong C*, Cai Z*. Pollution characteristics of ambient PM2.5-bound PAHs and NPAHs during winter time in Taiyuan. Chinese Chemical Letters 2014, 25: 663-666.

65. Li R*, Tian J, Li W, Cheng F, Gao G. Effect of 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine on oxidative stress and gene expression of c-fos, c-jun, p16 and Rb in rat colons and protective role of seabuckthorn seed oil. J. Environ. Sci. Heal. B. 2014, 49: 279-289.

66. Li R, Zhou Y, Ren G, Wang L*, Zou E. Effects of cadmium alone and in combination with low molecular weight chitosan on metallothionein, glutathione-S-transferase, acid phosphatase, and ATPase of freshwater crab  Sinopotamon yangtsekiense . Environ. Toxicol.2014, 29(3): 298-309.

67. Wu Y, Zhou H, Wu K, Lee S, Li R, Liu X*.PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress. Antioxid. Redox. Signal. 2014, 20(9): 1382-1395.

68. Li R*, Tian J, Li W, Xie J. Effects of 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) on histopathology, oxidative stress, and expression of c-fos, c-jun and p16 in rat stomachs. Food Chem. Toxicol. 2013, 55: 182-191.

69. Li R, Zhou Y, Wang L*, Ren G. Low-molecular-weight-chitosan ameliorates cadmium-induced toxicity in the freshwater crab,  Sinopotamon yangtsekiense . Ecotox. Environ. Safe. 2011,74(5): 1164-1170.

70. Li R, Zhou Y, Ji J, Wang L*. Oxidative damages by cadmium and the protective effects of low-molecular-weight chitosan in the freshwater crab ( Sinopotamon yangtsekiense Bott 1967 ). Aquacul. Res. 2011,42(4): 506 -515.

71. Li R, Yuan C, Dong C, Shuang S*, Choi M F*. In vivo antioxidative effect of isoquercitrin on cadmium-induced oxidative damage to mouse liver and kidney. Naunyn-Schmied. Arch. Pharmacol. 2011, 383(5): 437-445.

72. Li J, Li R, Meng Z*. Sulfur dioxide upregulates the aortic nitric oxide pathway in rats. European Journal of Pharmacology. 2010,645: 143-150.

73. Xie J, Li R, Meng Z*. Effects of sulfur dioxide on expressions of p53,bax and bcl-2 in lungs of asthmatic rats. Inhal. Toxicol. 2009,21(11): 952-957.

74. Li R, Meng Z*, Xie J.Effects of Sulfur Dioxide on the Expressions of EGF, EGFR, and COX-2 in Airway of Asthmatic Rats. Arch. Environ. Contam. Toxicol.2008,54: 748-757.

75. Li R, Meng Z*, Xie J.Effects of sulfur dioxide on the expressions of MUC5AC and ICAM-1 in airway of asthmatic rats.Regul. Toxicol. Pharmacol. 2007, 48(3): 284-291.

76. Li R, Meng Z*, Xie J.Effects of sulfur dioxide derivatives on four asthma-related gene expressions in human bronchial epithelial cells.Toxicol. Lett. 2007, 175(1-3): 71-81.

77. Li R, Meng Z*.Effects of SO2 derivatives on expressions of MUC5AC and IL-13 in human bronchial epithelial cells. Arch. Toxicol. 2007, 81(12): 867-874.

78. Meng Z*, Li R, Zhang X.Levels of sulfite in three organs from mice exposed to sulfur dioxide. Inha.l Toxicol. 2005, 17(6): 309-13.

79. 马慧,党玲,刘阳,李瑞金,刘洋*. 太原市绿地碳汇影响因素及其碳汇价值探究.环境生态学,2024,6(12),25-30.

80. 李瑞金,李志平,董川*.绿色低碳发展与“5R”原则.新兴科学和技术趋势, 2023, 2(3), 250-257.

81. 陈帆,刘洋,李瑞金*.“双碳”战略引导下煤炭生产企业碳排放核算的研究进展.新兴科学和技术趋势, 2023, 2(3), 241-249.

82. 李志平, 方明, 杨智, 陈茂阳, 余文婕, 岳建伟, 李素清, 李瑞金*.融雪剂对路域植物和土壤的影响及其耐性植物筛选.草原与草坪,2024,44(5):158-165.

83. 陈姗姗,陈文其,翁建霖,李瑞金*.PM2.5致心脏损伤的表观遗传学机制的研究进展.毒理学杂志,2022,36(2):174-177.

84. 李瑞金*,郝乾龙,刘洋,董川,翁建霖. 山西四城市大气污染特征及PM2.5传输规律研究. 山西大学学报(自然科学版), 2021, 44(5):1031-1044.

85. 白丽荣, 龚航远, 徐敏, 杨迪*,刘亮亮, 李素清,李瑞金*. 太原市某垃圾填埋场渗滤液及周边环境重金属污染及健康风险评估[J]. 生态毒理学报,2021, 16(4): 313-322

86. 郝乾龙,翁建霖,李瑞金*. 山西典型地区冬季大气PM2.5传输路径和潜在源分析. 环境与健康杂志,2020,37(4):1092-1096.

87. 白丽荣, 谭子康, 龚航远, 耿红,董川,李瑞金*. 大气PM2.5全身系统暴露对大鼠多脏器病理、氧化应激指标和炎症因子的影响. 生态毒理学报, 2020, 15(6):900-905.

88. 赵宇飞, 毛伟, 庞立新, 李瑞金*, 李素清. 人工湿地污水处理系统中芦苇和茭白生理特性及抗逆性[J]. 中国农学通报, 2020, 36(8): 60-66.

89. 张玫,李瑞金*.短链氯化石蜡环境暴露及毒理学效应研究进展[J].环境与健康杂志,2019,36(2):178-181.

90. 王影,张玫,赵利芳,张薇,赵婷,储靖璇,邱琰皓,龚航远,李瑞金*. 四溴双酚A对玉米种子发芽和根伸长及氧化损伤指标的影响[J].环境与健康杂志,2018,7:590-593.

91. 张玫,赵利芳,王影,苏瑞军,刘晓娜,李卓玉,李瑞金*. 大气细颗粒物亚慢性染毒对大鼠肺内质网应激相关因子表达的影响[J].环境科学学报,2017,37(11):4444-4448.

92. 赵利芳, 张书源, 佟金龙, 闫宇超, 徐冲, 孟紫强, 李瑞金*. PM2.5和SO2复合暴露对大鼠心脏病理学及炎症因子表达的影响[J]. 环境科学学报, 2017,37(5): 2006-2011.

93. 李瑞金*,张玫,赵利芳,王影,苏瑞军,刘小娜,李卓玉. 太原市冬夏季PM2.5亚慢性染毒对大鼠肺炎症因子和CK-18表达的影响[J]. 山西大学学报, 2017,40(3):622-627.

94. 李瑞金, 赵利芳, 王振涛, 翟苗苗, 白云龙, 张全喜, 李君灵.* PM2.5对运动大鼠肺氧化损伤和炎症反应相关指标的影响[J].环境与健康杂志,2016,33(2):175-178.

95. 李瑞金,耿红,蔡宗苇,宋沼鹏,徐丽敏,陈洁,陈鸣晖.太原市冬季PM2.5中多环芳烃、硝基多环芳烃、SO42-和NO3-的污染特征[J]. 建材技术与应用, 2014, 177(1):13-15.

96. 麻能轩,穆丽晓,李瑞金,周叶红,双少敏*.头孢哌酮和乳酸环丙沙星与人血清白蛋白相互作用的荧光光谱研究.中国药房,2013, 24(33):3084-3086.

97. 李瑞金,孟紫强*. SO2暴露对哮喘大鼠Th1/Th2平衡及TNF-α和Foxp3表达的影响[J].中国药理学与毒理学杂志,2013,27,增刊(1):38.

98. 樊冰心, 任国锐, 李瑞金, 王兰*.低分子质量壳聚糖对镉胁迫引起河南华溪蟹氧化损伤的保护作用[J]. 食品科学, 2013, 34(11):228-231.

99. 任国锐, 李瑞金, 王兰*.低分子量壳聚糖对鲤鱼生长和消化酶活性的影响[J]. 食品科学, 2013,34 (1): 8-12.

100. 解静芳*,韩琦,杨彪,郝婷娟,张秋华,李瑞金,范仁俊.多环芳烃活性参数与色谱保留指数相关性分析[J].生态毒理学报,2012,7:107-112.

101. 解静芳*,郝婷娟,刘丽娜,金国文,郭小君,李瑞金.内毒素致大鼠肝组织氧化应激作用[J]. 环境与职业医学, 2012,29:154-157.

102. 李瑞金,李万青,解静芳,张月霞.杂环胺代表物PhIP对大鼠不同组织脂质过氧化作用的影响[J].卫生研究, 2012, 41(1):102-104.

103. 李瑞金,李万青,解静芳.2-氨基-1-甲基-6-苯基-咪唑并[4, 5-b]吡啶对大鼠不同组织的蛋白质氧化损伤作用[J].环境与健康杂志,2011, 28(11):961-963.

104. 周妍英,李瑞金,任国锐,王兰*.镉对长江华溪蟹金属硫蛋白mRNA表达的诱导及低分子量壳聚糖的联合作用[J]. 环境科学学报,31(9):2028-2032.

105. 李瑞金,董川*.烧烤、腌制和隔夜食物的化学与健康问题[J]. 化学通讯,2010,4:75-76.

106. 解静芳*,崔宏莉,金国文,刘小娟,郭晓君,李瑞金.内毒素对小鼠肺、肝和心氧化损伤作用[J].中国公共卫生,2009,25(12):1511-1512.

107. 解静芳,金国文,李瑞金,王学峰,刘丽娜,孟紫强*.在大鼠哮喘发生中SO2致凋亡相关基因及蛋白质表达的改变[J].环境科学学报,2009, 29(3):613-618.

108. 袁超,李瑞金*,宋秀丽,双少敏.异槲皮苷与BSA的作用及铁锌离子对反应的影响[J].应用化学增刊,2009, 26:343-345.

109. 李瑞金,孟紫强*.SO2衍生物对人BEP2D细胞哮喘基因表达的影响[J].中国公共卫生,2007,23(12):1457-1460.

110. 李瑞金,孟紫强*,李晓芳.二氧化硫染毒小鼠部分脏器中亚硫酸盐的高效液相色谱测定法及毒理学效应[J].环境与健康杂志,2006,23(5):405-408.

111. 李瑞金,解静芳*,范仁俊,高越.降尘和酸雨对芹菜中重金属分布特征的研究[J].华北农学报,2006,21(4):75-78.

112. 李瑞金,孟紫强*,张波.二氧化硫衍生物对小鼠肝细胞DNA损伤的研究[J].山西医科大学学报(自然科学版),2005,36(2):177-179.

113. 孟紫强,李瑞金,张欣.HPLC荧光检测法测二氧化硫吸入后小鼠脑、心和肺亚硫酸盐水平[J]. 环境科学学报,2005,25(3):346-350.

114. 秦国华,李瑞金,孟紫强*,张波.二氧化硫对小鼠不同脏器DNA的损伤作用[J].中国环境科学, 2005,25(4):424-427.

115. 孟紫强,李瑞金,白巨利,张欣,杨振华.二氧化硫亚慢性染毒对大鼠肺细胞DNA的损伤作用[J].应用与环境生物学报,2005,11(6):726-728.

116. 孟紫强,李瑞金,白巨利,张全喜,李屹.亚硫酸钠对小鼠不同脏器的DNA损伤[J].食品科学,2005,26(10):203-205.

117. 李瑞金,孟紫强*,张波.二氧化硫体内衍生物对小鼠胃细胞DNA损伤的研究[J].山西大学学报(自然科学版),2004,27(2):205-208.

二、主持或参与的主要课题

1. 国家基金面上项目:运城盐湖湿地土壤微生物硫代谢驱动机制及环境适应机制(No. 42477031),47万元,2025.1-2028.12,参加(第三),在研

2. 山西省中医药局项目:白藜芦醇对肠易激综合征小鼠肠道损伤的保护作用及机制研究(2024ZYYB052),2024.1-2026.12,主持,2万元

3. 国家自然科学基金项目:基于代谢组学和质谱成像技术探讨大气细颗粒物对孕早期胚胎停育的影响及机制(No.

22176116),60万元,2022.1-2025.12,主持,在研

4. 山西省科技厅社会发展项目:山西典型地区大气细颗粒物中新型污染物分析及溯源研究(201903D321079),2019.12-2021.12,10万元,主持,结题

5. 山西省自然科学基金项目:SIRT3在PM2.5致心脏线粒体动力学失衡中的作用机制研究(201801D121260),2018.12-2020.12,5万元,主持,结题

6. 2019年1331太原市大气细颗粒物污染特征及毒理学效应研究(2019KJ003),2019.12-2020.12,5万元,结题,主持

7. 2019横向项目:太原市某垃圾填埋场渗滤液中抗生素及抗性基因污染特征研究,2020.1-2022.12,4万元,在研,主持

8. 2018横向项目:太原市生活垃圾卫生填埋场渗滤液对周边环境影响研究,2018.1-2021.12. 4.5万元,在研,主持

9. 2017横向项目:太原市大气细颗粒物采样及毒理分析,2017.9-2020.9. 4.6万元,结题,主持

10. 2017年山西省百人计划项目,2017.7-2022.7,50万元,在研,主持

11. 国家自然科学基金项目:大气细颗粒物毒性组分甄别研究(No. 91843301),2019.01-2021.12,50万元,在研,参加

12. 国家自然科学基金重点项目:太原和广州市大气细颗粒物诱导呼吸系统疾病的质谱代谢组学研究(No. 91543202),2016.1-2019.12,65万元,结题,参加

13. 国务院及其他部委项目:山西调查地区居民环境金属总暴露调查(一期)(No. 2111101),2018.7-2019.2,50万元,在研,参加

14. 2016横向项目:太原市生活垃圾卫生填埋场渗滤液采样分析,2016.9-2019.12. 8.1万元,主持,结题

15. 2016年省级配套国家科研项目经费,2017.1-2018.12,20万元,主持,结题

16. 山西省自然科学基金项目:乳腺癌细胞MCF7B中早老素在EpCAM水解代谢过程中的作用及对细胞功能的调控(No. 201701D221153),2017.8-2019.12,2万元,结题,参加,第三

17. 山西省自然科学基金项目:二氧化硫引起血管舒张的PI3K/Akt/eNOS信号通路机制研究(No. 201601D0110821),2016.8-2018.12,3万元,结题,参加,第二

18. 山西省自然科学基金项目:太原市高校宿舍大气环境与学生呼吸道疾病的健康-效应研究(No. 2016011080),2016.8-2018.12,3万元,结题,参加,第三

19. 山西省科技厅项目:灰霾天气PM2.5硝基多环芳烃污染特征及毒理学效应研究(No. 2014110),2015.1-2016.12,4万元,主持,结题

20. 山西省自然科学基金项目:山西省大气细颗粒物硝基多环芳烃污染特征及毒理和健康效应研究(No. 2014011036-2),2014.1-2016.12,3万元,主持,结题

21. 山西省回国留学人员科研项目:细颗粒物和SO2诱导呼吸系统炎症的分子机制研究(No. 2013-016)2013.7-2015.12,5 万元,主持,结题

22. 国家火炬计划项目:低品位盐湖钾矿高效开采与加工(No. 2013140104000015)2012/1-2014/1,27.9 万元,主持,结题

23. 镉对溪蟹组织氧化损伤和钙稳态的影响及壳聚糖的预防效应,2010年中国博士后科学基金面上项目(No. 20100471580),主持,3万元结题

24. 山西省自然环境与资源研究,省市级、横向课题,主持,2010年 4万元结题

25. P16作为生物标记研究杂环胺对大鼠胃的早期损伤,山西省自然科学基金(No. 2009011039-1),主持,2009.1-2011.12,5万元,结题

26. 山西省环保局委托项目:山西省燃煤企业烟气脱硫技术的评价研究, 2008.8-2009.8,2万,主持,结题

27. 山西省潞安环保委托项目:煤层固化材料的研究与应用(2008.8-2010.12),15万,主持,结题

28. 校科研基金项目:HPLC法测定SO2暴露后小鼠组织中亚硫酸盐含量(No. 2006009),主持,结题

29. 山西省教育厅专项:山西工矿区PAHs和重金属复合污染土壤的植物修复模式研究 (No. 201100007)3万元,2012.1-2014.12,参加,排名第四,结题

30. 山西省国际科技合作项目:中加合作山西工矿区PAHs(多环芳烃)和重金属复合污染土壤-微生物联合修复技术(No. 2012081010), 20万元,2012.1-2013.12,参加,排名第六,,结题

31. 山西省科技攻关计划:壳聚糖作为绿色水产养殖饲料添加剂的研究和开发(No. 20100311050),2010.1-2012.12,10万元,参加,排名第二,,结题

32. 山西省自然科学基金:城市大气PM2.5单颗粒成分变化对肺泡巨噬细胞线粒体融合/分裂功能的影响(No. 2011011009-2),2011.1-2013.12,5万元,参加,排名第二,结题

33. 省市级、横向课题:一种无尘板书写液及其擦剂,2011年,15万元,参加,排名第二,结题

34. 山西省回国留学人员科研项目:镉诱导溪蟹金属硫蛋白在细胞的定位与原核表达, (No. 201015),2010.8-2012.12,7 万元,参加,排名第三,结题

35. 国家自然科学基金:内毒素诱发哮喘大鼠气道高反应性基因表达研究(No. 30740037),2008.1-2008.12,参加,排名第二,结题

36. 国家自然科学基金:二氧化硫及其衍生物对大鼠组织细胞和培养人支气管上皮细胞原癌基因和抑癌基因表达的影响(No. 20477023),2005.1-2007.12,23万元,参加,排名第五,结题

37. 国家自然科学基金:二氧化硫对小鼠肺脏和人肺细胞凋亡及氧化损伤的效应(No.30070647),2001.1-2003.12,参加,排名第十,结题

38. 山西省自然科学基金:基于NKG2D配体表达模式的二氧化硫毒性机制研究(No.2009011039-2),2009.1-2011.12,5万元,参加,排名第三,结题

三、获奖

1. 2019年度山西省科学技术奖(自然科学奖)二等奖(2019-Z-014),排名第四,获奖人名单:张全喜,杨振华,李君灵,李瑞金,孟紫强,项目名称:大气主要污染物二氧化硫和沙尘暴颗粒物对呼吸和心血管系统的毒理效应,2021年3月

2. 2018年度山西省科学技术奖(自然科学奖)三等奖(2018-Z-006),排名第一,获奖人名单:李瑞金,董川,蔡宗苇,解静芳,耿红,项目名称:太原市大气细颗粒物污染特征及毒理学效应研究,2020年1月

3. 2019年度山西省高等学校优秀成果奖(科学技术)二等奖(2019KJ003),排名第一,获奖人名单:李瑞金,董川,蔡宗苇,解静芳,耿红,项目名称:太原市大气细颗粒物污染特征及毒理学效应研究,2019年7月

4. 2009年获得山西省科技进步一等奖(排名第五,获奖人名单为:孟紫强、解静芳、张波、刘晓莉、李瑞金、张全喜),项目名称:典型大气污染物毒理作用的系列研究。

5. 2008年8月获得山西省高等学校科技进步一等奖(排名第五,获奖人名单为:孟紫强、解静芳、张波、刘晓莉、李瑞金),项目名称:典型大气污染物毒理作用的系列研究。

6. 中国环境科学学会第十届优秀环境科技工作者奖,2014.12, 个人奖

四、专著

1. 孟紫强,张全喜,杨振华,李君灵,李瑞金.环境毒物史,北京:中国环境出版集团,116万字,2022.9,本人承担32万字

2. 孟紫强,张全喜,杨振华,李君灵,李瑞金. 二氧化硫信号分子研究,北京: 中国环境出版集团,22.6 (万字) 本人承担6万字,2022.8

3. 孟紫强,郭新彪,郝卫东,马爱国,张志红,李瑞金,白剑英,张全喜,刘汝涛,安艳, 郭掌珍. 环境毒理学(第三版), 北京:高教出版社, 53万字, 2018.11.1

4. 孟紫强,张全喜,李瑞金,杨振华,世界毒物全史第55卷环境毒理学史,西安:西北大学出版社,1.25万字,2016年12月

5. 孟紫强,张全喜,李瑞金,张义贤. 现代环境毒理学,中国环境出版社,146.6 万字,2015年12月

6. 孟紫强, 李瑞金, 解静芳, 张全喜, 白巨利, 秦国华, 李君灵, 杨振华,

二氧化硫生物学:毒理学•生理学•病理生理学, 科学出版社, 47.4万字, 2012

7. 孟紫强, 张全喜, 李君灵, 李瑞金. 毒理学研究进展报告:环境毒理学研究进展报告, 科学出版社, 1.4万字, 2011

8. 孟紫强, 马爱国, 郭新彪, 朱茂祥, 郝卫东, 张波, 李瑞金, 张志红, 环境毒理学基础(第二版), 北京:高教出版社, 20万字, 高教出版社, 2010

9. 孟紫强,解静芳,李瑞金,张全喜,白巨利,秦国华, 生活方式与健康, 科普出版社, 18万字,2009年6月

五、会议

1. 白丽荣,龚航远,李志平,岳建伟,徐敏,杨迪,刘亮亮,李素清,李瑞金*.垃圾渗滤液和填埋场周边环境重金属污染特征及健康风险评估.黄河流域高质量发展与生态环境损害司法鉴定理论技术交流研讨会,河南郑州,2021.10.22-24

2. 李瑞金.参加2019 年环境与健康学术会议(中国·天津),会议论文题目:大气细颗粒物对人SH-SY5Y细胞线粒体损伤机制研究。获得会议颁发的优秀展板汇报奖。

3. 赵利芳,张丽,陈鸣晖,董川,李瑞金*,蔡宗苇*.大气PM2.5、1-NP和9-NA对大鼠心脏DNA损伤和氧化应激的影响,第十届全国环境化学大会会议,天津,2019.09.15-19,

4. 李瑞金,张玫,李志平,岳建伟,徐敏,蔡宗苇*,董川*.太原市冬夏季大气细颗粒物污染特征分析,中国中西部地区第六届色谱学术报告会,2018.7. 27-30,河南郑州

5. 王影,张玫,赵利芳,张薇,赵婷,储靖璇,邱琰皓,龚航远,李瑞金*.四溴双酚A对玉米种子发芽和根伸长及生理指标的影响,第五届生态毒理学学术研讨会,2018.4.25-28,辽宁大连

6. 李瑞金*,张玫,王影,赵利芳,苏瑞军,李卓玉. 太原冬季和夏季PM2.5亚慢性暴露对大鼠肝纤维化及其相关基因表达的影响.环境与公共健康学术会议,2017.11.10-13,广东广州

7. 李瑞金,张玫,王影,赵利芳,苏瑞军,李卓玉,蔡宗苇.* 太原冬季和夏季PM2.5亚慢性暴露对大鼠肺内质网应激和炎症基因表达的影响,第九届全国环境化学大会,2017.10.19-22,浙江杭州

8. 张玫,赵利芳,苏瑞军,刘小娜,李瑞金*.太原市冬夏季大气PM2.5暴露对大鼠肝组织病理学、肝功能及代谢酶的影响,中国环境科学学会环境医学与健康分会2016 年会,2016.11.4-6,江苏南京

9. 李瑞金,寇晓晶,耿红,解静芳,田晶晶,蔡宗苇*,董川*.细颗粒物暴露对大鼠心脏线粒体损伤效应及分子机制研究.全国环境医学与健康大会,53-54. 2015.10.31-11.2,福建厦门

10. 李瑞金*,赵利芳,张丽,陈鸣辉.大气细颗粒物和9-硝基蒽对大鼠肺DNA的损伤作用及机制,第八届全国环境化学大会会议,2015.11.5-11.8,广东广州

11. 李瑞金,寇晓晶,田晶晶, 耿红*. PM2.5暴露对大鼠肺线粒体融合/分裂基因表达的影响,第七届全国环境化学大会会议2013.09.22-25,贵州贵阳

12. 李瑞金,孟紫强*.二氧化硫对哮喘大鼠肺组织哮喘相关基因表达的影响,环境与健康研讨会,2010.7.17-20,广东广州,T2:24 会议论文

指导研究生获得研究生创新项目

2023年,基于HIF-1α通路的大气细颗粒物PM2.5致小鼠脑损伤(李瑞金研究生:陈文其)

2024年,PM2.5加重IBS-D小鼠肠道损伤机制及白藜芦醇缓解作用的研究(李瑞金研究生:李唐)